Hydrochloric Acid → 7,7-Dimethyl-4,5,6,7-tetrahydro-thieno[3,4-c]pyridine

HRID 74537Notes

Reaction equation

HRID 74537 reaction equation
[CH2:1]=[N:2][CH2:3][C:4]([CH3:11])([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)[CH3:5].Cl.[OH-].[Na+]>>[CH3:5][C:4]1([CH3:11])[CH2:3][NH:2][CH2:1][C:10]2=[CH:9][S:8][CH:7]=[C:6]12

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 14798Sodium HydroxideHCID 58117475Methylene-(2-methyl-2-thiophen-3-yl-propyl)-amine

Product 1

HCID 583866507,7-Dimethyl-4,5,6,7-tetrahydro-thieno[3,4-c]pyridine

Procedure

6.00 g (35.9 mmol) methylene-(2-methyl-2-thiophene-3-yl-propyl)-amine, 11.3 mL (45.3 mmol) 4M HCl and 11.8 mL (142 mmol) conc. HCl were stirred at RT over the weekend. The reaction mixture was made alkaline with 4M NaOH solution. The precipitate formed was suction filtered, washed with water and dried. The substance was purified through Alox. The product-containing fractions were combined and concentrated to dryness by rotary evaporation.

Workup

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed with water
  4. customdried
  5. customThe substance was purified through Alox
  6. concentrationconcentrated to dryness by rotary evaporation

Sources & evidence

ORD record
ord-767d7465fd064703bbc7176dc02e3316
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Reaction notes

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