HCID 23315738, compound → HCID 23315735, compound

HRID 745390Notes

Reaction equation

HRID 745390 reaction equation
Cl[CH2:2][C:3]1[CH:21]=[CH:20][C:6]([CH2:7][O:8][N:9]2[C:13](=[O:14])[C:12]3=[CH:15][CH:16]=[CH:17][CH:18]=[C:11]3[C:10]2=[O:19])=[CH:5][CH:4]=1.[C:22]1(=[O:32])[NH:26][C:25](=[O:27])[C:24]2=[CH:28][CH:29]=[CH:30][CH:31]=[C:23]12.[K]>CN(C)C=O>[C:22]1(=[O:32])[N:26]([CH2:2][C:3]2[CH:21]=[CH:20][C:6]([CH2:7][O:8][N:9]3[C:13](=[O:14])[C:12]4=[CH:15][CH:16]=[CH:17][CH:18]=[C:11]4[C:10]3=[O:19])=[CH:5][CH:4]=2)[C:25](=[O:27])[C:24]2=[CH:28][CH:29]=[CH:30][CH:31]=[C:23]12

Participants

4

Reactant 2

HCID 23315738HCID 23315738, compoundHCID 24194345Phthalimide potassium salt

Product 1

HCID 23315735HCID 23315735, compoundYield 83.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of N-(4-chloromethylbenzyloxy)phthalimide (18.5 g.) and potassium phthalimide (15.4 g.) in N,N-dimethylformamide (180 ml.) was stirred at 60° C. for 5 hours. The mixture was poured into ice-water and the precipitates were collected by filtration. The precipitates were washed with water and acetone in turn to give N-(4-phthalimidomethylbenzyloxy)-phthalimide (21.0 g.).

Workup

  1. filtrationthe precipitates were collected by filtration
  2. washThe precipitates were washed with water and acetone in turn

Sources & evidence

ORD record
ord-3c73acd3654f4d6e8f4cac7c90a0cc99
Source dataset
uspto-grants-1986_07
Patent number
US04598147

Reaction notes

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