Water → HCID 58386473, compound

HRID 74542Notes

Reaction equation

HRID 74542 reaction equation
[F:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH3:14])([CH3:13])[C:5](=O)[NH:6]2.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>C1COCC1>[F:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH3:14])([CH3:13])[CH2:5][NH:6]2

Participants

5

Reactant 3

HCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 58386652HCID 58386652, compound

Product 1

HCID 58386473HCID 58386473, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
70 °C

Procedure

0.15 mg (0.76 mmol) 4,5-difluoro-3,3-dimethyl-1,3-dihydro-indol-2-one were placed in 20 mL THF under argon. 0.91 mL (0.91 mmol) of a 1M lithium aluminium hydride solution in 10 mL THF were added dropwise. The reaction mixture was stirred for 1 h at 70° C., cooled and mixed with water. The reaction mixture was dried, filtered and concentrated to dryness by rotary evaporation.

Workup

  1. temperaturecooled
  2. customThe reaction mixture was dried
  3. filtrationfiltered
  4. concentrationconcentrated to dryness by rotary evaporation

Sources & evidence

ORD record
ord-286090fd038a409e85f399d7273b1b32
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Reaction notes

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