Methanol → HCID 58386742, compound

HRID 74543Notes

Reaction equation

HRID 74543 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[NH:7][C:6](=[O:12])[CH2:5]2.[CH3:13]O>[Ni]>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[NH:7][C:6](=[O:12])[CH:5]2[CH3:13]

Participants

4

Reactant 2

HCID 887MethanolHCID 125852825,6-Difluorooxindole

Product 1

HCID 58386742HCID 58386742, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

1.5 g (9.0 mmol) 5,6-difluoro-1,3-dihydro-indol-2-one were stirred with 1.0 g Raney nickel in 50 mL methanol 3 h at 200° C. in an autoclave. The catalyst was filtered off and the filtrate was concentrated to dryness by rotary evaporation.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated to dryness by rotary evaporation

Sources & evidence

ORD record
ord-6ca0e0dd9fcd45d8af65ab1cfe62807c
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Reaction notes

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