Methanol → 2H-Indol-2-one, 5-fluoro-1,3-dihydro-3-Methyl-

Participants

Reaction Steps

3.0 g (20 mmol) 5-fluoro-1,3-dihydro-indol-2-one were stirred with 2.0 g Raney nickel in 50 mL methanol for 1.5 h at 200° C. in an autoclave. The catalyst was filtered off and the filtrate was concentrated to dryness by rotary evaporation. The residue was recrystallised from methanol, suction filtered and dried.

Provenance & Evidence