Water → HCID 58386460, compound

HRID 74546Notes

Reaction equation

HRID 74546 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=O)[C:5]2([CH2:13][CH2:14][O:15][CH3:16])[CH3:12].[H-].[Al+3].[Li+].[H-].[H-].[H-].O>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH2:6][C:5]2([CH2:13][CH2:14][O:15][CH3:16])[CH3:12]

Participants

5

Reactant 3

HCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 58386493HCID 58386493, compound

Product 1

HCID 58386460HCID 58386460, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
70 °C

Procedure

Under an argon atmosphere 0.12 g (0.54 mmol) 5-fluoro-3-(2-methoxy-ethyl)-3-methyl-1,3-dihydro-indol-2-one were placed in 20 mL THF. 0.56 mL (0.56 mmol) of a 1M lithium aluminium hydride solution in 10 mL THF were added dropwise. The reaction mixture was stirred for 1 h at 70° C., then mixed with water and dried, filtered and concentrated to dryness by rotary evaporation.

Workup

  1. customdried
  2. filtrationfiltered
  3. concentrationconcentrated to dryness by rotary evaporation

Sources & evidence

ORD record
ord-e4eb0cf0bbd9460dbae91c6eb1cef978
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Reaction notes

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