反应详情

5 g of 1-hexadecyloxy-3-methylamino-propan-2-ol are dissolved in 30 cc. of anhydrous chloroform. At first 3 g of triethylamine and separately thereafter 2.4 g of acetylchloride are added dropwise with cooling and the mixture is stirred for 8 hours. The chloroform solution is washed with 2% hydrochloric acid and water, is evaporated and the residue is dissolved in 100 cc. of methanol. A solution of 0.6 g of sodium hydroxide in a little methanol is added to the methanol solution and the mixture is stirred at room temperature for one hour. The solvent is evaporated in a vacuo and the residue is triturated in chloroform. The chloroform solution is washed with 2% hydrochloric acid and water, is dried over sodium sulfate and is evaporated.

1. temperaturewith cooling
2. washThe chloroform solution is washed with 2% hydrochloric acid and water
3. customis evaporated
4. dissolutionthe residue is dissolved in 100 cc
5. additionA solution of 0.6 g of sodium hydroxide in a little methanol is added to the methanol solution
6. stirringthe mixture is stirred at room temperature for one hour
7. customThe solvent is evaporated in a vacuo
8. customthe residue is triturated in chloroform
9. washThe chloroform solution is washed with 2% hydrochloric acid and water
10. dry with materialis dried over sodium sulfate
11. customis evaporated