反应详情

21.2 g of sodium fluoride are added to a solution of 107.8 g of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-cyclopropylaminoacrylate in 400 ml of anhydrous dimethylformamide. The reaction mixture is then stirred under reflux for 2 hours and poured hot onto ice. The precipitate is filtered off with suction, thoroughly washed with water, and dried over calcium chloride at 100° C. in vacuo. 91.2 g of ethyl 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate of melting point 167°-168° C. are obtained.

1. temperatureunder reflux for 2 hours
2. additionpoured hot onto ice
3. filtrationThe precipitate is filtered off with suction
4. washthoroughly washed with water
5. dry with materialdried over calcium chloride at 100° C. in vacuo