反应详情

To a suspension of 1.32 g of 61% sodium hydride in 20 ml of benzene was added dropwise at room tmperature a solution of 2.6 g of 2-methyl-2-aminopropanethiol in 10 ml of benzene. Then, a solution of 4.1 g of 3,6-dichloropyridazine in 10 ml of benzene was added, and the mixture was refluxed for 6 hours. After cooling, the reaction mixture was washed with water and dried over magnesium sulfate. The solvent was evaporated to give 1.96 g of 3-(2-amino-2-methylpropylthio)-6-chloropyridazine.

1. temperaturethe mixture was refluxed for 6 hours
2. temperatureAfter cooling
3. washthe reaction mixture was washed with water
4. dry with materialdried over magnesium sulfate
5. customThe solvent was evaporated