反应详情

A mixture of 0.62 g of 60% sodium hydride, 1.91 g of 3,6-dichloropyridazine and 10 ml of benzene was stirred while being cooled with ice, and a solution consisting of 1.32 g of 3-amino-3-methylbutanol, 3 ml of t-butanol and 5 ml of benzene was added dropwise. After stirring at room temperature for 30 minutes, ether was added to the reaction mixture, and the solid was removed by filtration with Hyflo Super-Cel. The filtrate was concentrated under reduced pressure. n-Hexane was added to the resulting oily product, and the mixture was allowed to stand to give 2.34 g of 3-(3-amino-3-methylbutoxy)-6-chloropyridazine as colorless crystals having a melting point of 63.5° to 65.0° C.

1. temperaturewhile being cooled with ice
2. additionwas added dropwise
3. stirringAfter stirring at room temperature for 30 minutes
4. customthe solid was removed by filtration with Hyflo Super-Cel
5. concentrationThe filtrate was concentrated under reduced pressure
6. additionn-Hexane was added to the resulting oily product