反应详情

A micture of 4.3 g of 1-(2-methylphenoxy)-2,3-epoxypropane, 7.03 g of N,N-dibenzyl-2-methyl-1,2-propanediamine and 50 ml of ethanol was refluxed for 20 hours, and the solvent was evaporated under reduced pressure. To a benzene solution of the residue was added 1N hydrochloric acid, to deposit an oily material. After removal of the benzene layer, the residue was extracted with chloroform. The organic layer was washed with 5% sodium carbonate and dried over anhydrous sodium sulfate. The solvent was evaporated to give a colorless oily product. The product was chromatographed on a column of silica gel using chloroform as an eluent. 7.3 g of 1-(2-methylphenoxy)-3-(1,1-dimethyl-2-dibenzylaminoethylamino)-2-propanol was obtained from the eluate.

1. customthe solvent was evaporated under reduced pressure
2. additionTo a benzene solution of the residue was added 1N hydrochloric acid
3. customAfter removal of the benzene layer
4. extractionthe residue was extracted with chloroform
5. washThe organic layer was washed with 5% sodium carbonate
6. dry with materialdried over anhydrous sodium sulfate
7. customThe solvent was evaporated
8. customto give a colorless oily product
9. customThe product was chromatographed on a column of silica gel