Tetrahydrofuran → HCID 58386443, compound

HRID 74552Notes

Reaction equation

HRID 74552 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:19][CH2:18][N:17]([C:20]4[N:25]=[CH:24][N:23]=[C:22]([C:26]([O:28]C)=[O:27])[N:21]=4)[CH2:16][CH2:15]3)[CH2:9][CH2:8][C:7]=2[CH:30]=1.[OH-].[Na+].C1COCC1>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:15][CH2:16][N:17]([C:20]4[N:25]=[CH:24][N:23]=[C:22]([C:26]([OH:28])=[O:27])[N:21]=4)[CH2:18][CH2:19]3)[CH2:9][CH2:8][C:7]=2[CH:30]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 58386563Methyl 4-[4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-[1,3,5]triazine-2-carboxylate

Product 1

HCID 58386443HCID 58386443, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.27 g (0.64 mmol) methyl 4-[4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-[1,3,5]triazine-2-carboxylate and 0.5 mL (2 mmol) of a 4M NaOH solution were stirred in 0.5 mL water and 4.0 mL THF for 3 days at RT. The organic solvent was eliminated by rotary evaporation and the reaction mixture was combined with 0.5 mL of a 4M HCl solution. The precipitated solid was suction filtered and dried.

Workup

  1. customThe organic solvent was eliminated by rotary evaporation
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-2c5d1e5cbc144fb6b9aa1976833b3527
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Reaction notes

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