1-(2-Bromoethyl)-4-chlorobenzene → HCID 10754978, compound

HRID 745537Notes

Reaction equation

HRID 745537 reaction equation
[P:1]([O:8][CH2:9][CH3:10])([O:5][CH2:6][CH3:7])[O:2]CC.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19]Br)=[CH:14][CH:13]=1>>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][P:1](=[O:2])([O:5][CH2:6][CH3:7])[O:8][CH2:9][CH3:10])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 230291-(2-Bromoethyl)-4-chlorobenzeneHCID 31215Triethyl phosphite

Product 1

HCID 10754978HCID 10754978, compound

Procedure

Combine 24.9 g (0.15 mole) of triethyl phosphite and 32.9 g of 2-(4-chlorophenyl)ethyl bromide. Heat the mixture at reflux under a nitrogen atmosphere for 5-6 hours. Distill the reaction mixture at reduced pressure (0.2 mm Hg) and collect the fraction distilling at 110°-148° C. to obtain the title compound.

Workup

  1. temperatureHeat the mixture
  2. temperatureat reflux under a nitrogen atmosphere for 5-6 hours
  3. distillationDistill the reaction mixture at reduced pressure (0.2 mm Hg)
  4. customcollect the fraction
  5. distillationdistilling at 110°-148° C.

Sources & evidence

ORD record
ord-54f4ab5672da47789a3d5ce29e6c156d
Source dataset
uspto-grants-1986_07
Patent number
US04599344

Reaction notes

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