Hydrochloric Acid → HCID 178517116, compound

HRID 74557Notes

Reaction equation

HRID 74557 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[C:16](Cl)=[N:17][C:18]3[C:23]([CH:24]=2)=[CH:22][CH:21]=[CH:20][CH:19]=3)(O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[OH2:27]>>[CH2:1]([N:8]1[CH2:13][CH:12]=[C:11]([C:15]2[C:16]([OH:27])=[N:17][C:18]3[C:23]([CH:24]=2)=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 184442481-Benzyl-4-(2-chloroquinolin-3-yl)piperidin-4-ol

Product 1

HCID 178517116HCID 178517116, compound

Procedure

15.5 g (43.9 mmol) 1-benzyl-4-(2-chloro-quinolin-3-yl)-piperidin-4-ol were refluxed for 8 h in 150 mL of a 6M aqueous hydrochloric acid solution. 100 mL water were added dropwise to the reaction mixture and the precipitated solid was suction filtered, dried and then stirred into 150 mL of a 15%, aqueous potassium carbonate solution. After the precipitate had been suction filtered the product was obtained as a free base and dried.

Workup

  1. filtrationfiltered
  2. customdried
  3. filtrationfiltered the product
  4. customwas obtained as a free base
  5. customdried

Sources & evidence

ORD record
ord-9c42c06d9fa44c77b7d3e85da584db65
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Reaction notes

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