反应详情

To the suspension of 1.0 g of 3,3-dimethylindoline-2-carboxylic acid hydrochloride in 25 ml of methylene chloride, 1.33 g of triethylamine are added and the resulting solution cooled to -10°. The solution of 1.065 g of 3-benzoylthio-2-methylpropanoyl chloride in 5 ml of methylene chloride is added dropwise and the mixture stirred at -5° for 1 hour, and then at room temperature for 2 hours. It is evaporated, 10 ml of 3N hydrochloric acid are added to the residue and the mixture is extracted with methylene chloride. The extract is dried and evaporated, to give the 1-(3-benzoylthio-2-methylpropanoyl)-3,3-dimethylindoline-2-carboxylic acid.

1. additionare added
2. temperaturethe resulting solution cooled to -10°
3. waitat room temperature for 2 hours
4. customIt is evaporated
5. addition10 ml of 3N hydrochloric acid are added to the residue
6. extractionthe mixture is extracted with methylene chloride
7. customThe extract is dried
8. customevaporated