反应详情

In a hydrogen atmosphere 160 mg (0.46 mmol) 3-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-6-methoxy-quinolin-2-ol and 20 mg palladium on charcoal (10%) in 30 mL MeOH were hydrogenated for 17.5 h at 50° C. at 50 psi. Then another 10 mL THF and catalyst were added and the mixture was hydrogenated for a further 2 h. Catalyst was added again and the mixture was hydrogenated overnight at 50° C. in a hydrogen atmosphere of 60 psi. After filtration of the reaction mixture the filter cake was washed with DMF and the filtrate was evaporated down. The residue was added to EtOAc, triturated with PE and filtered. The precipitate was washed with diisopropylether and dried.

1. additionCatalyst was added again
2. filtrationAfter filtration of the reaction mixture the filter cake
3. washwas washed with DMF
4. customthe filtrate was evaporated down
5. additionThe residue was added to EtOAc
6. customtriturated with PE
7. filtrationfiltered
8. washThe precipitate was washed with diisopropylether
9. customdried