反应详情

0.37 g (0.52 mmol) of a mixture of tert. butyl 7,7-dimethyl-3-trifluoromethyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylate and tert. butyl 4-hydrazone-3,3-dimethyl-5-(2,2,2-trifluoro-acetyl)-piperidine-1-carboxylate in 8.0 mL DCM was combined with 4.0 mL trifluoroacetic acid and stirred for 2 h at RT. Then the reaction mixture was evaporated down, the residue was dissolved in EtOH, mixed with 0.90 mL (1.1 mmol) of a 1.25 molar ethanolic hydrochloric acid and co-evaporated again. The residue was triturated with diethyl ether, suction filtered and dried.

1. customThen the reaction mixture was evaporated down
2. dissolutionthe residue was dissolved in EtOH
3. additionmixed with 0.90 mL (1.1 mmol) of a 1.25 molar ethanolic hydrochloric acid
4. customThe residue was triturated with diethyl ether, suction
5. filtrationfiltered
6. customdried