Aluminium lithium hydride → 2-Methyl-5-(pyrrolidinomethyl)thiazole

HRID 745718Notes

Reaction equation

HRID 745718 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:7]([N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=O)=[CH:5][N:6]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CCOCC>[CH3:1][C:2]1[S:3][C:4]([CH2:7][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 233117232-Methyl-5-(pyrrolidinocarbonyl)thiazole

Product 1

HCID 235063512-Methyl-5-(pyrrolidinomethyl)thiazole

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 2-methyl-5-(pyrrolidinocarbonyl)thiazole in dry ether was added dropwise to a suspension of lithium aluminium hydride and the mixture was stirred at room temperature to give the title compound as a colourless liquid, b.p. 61-62°C.

Sources & evidence

ORD record
ord-9bada2e984af48fea3b3e4513a892e19
Source dataset
uspto-grants-1986_07
Patent number
US04600025

Reaction notes

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