Triethylamine → HCID 18793474, compound

HRID 745726Notes

Reaction equation

HRID 745726 reaction equation
Cl[C:2]([O:4]C1C=CC=CC=1)=[O:3].[N:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1N.C([N:20](CC)CC)C>N1C=CC=CC=1>[C:2](=[O:3])([O:4][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][N:11]=1)[NH2:20]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 104392-AminopyridineHCID 15891Phenyl chloroformate

Product 1

HCID 18793474HCID 18793474, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Procedure

The reaction of a haloformate, such as phenyl chloroformate, and a pyridinylamine generally is carried out by combining a slight excess of haloformate with the pyridine in an organic solvent, such as triethylamine or pyridine, and stirring the mixture for about 1 to about 24 hours at a temperature of about 0° to about 30° C. The product of the reaction, a pyridinyl carbamate, is generally isolated by acidifying the reaction mixture, for instance by the addition of a mineral acid, such as hydrochloric acid or sulfuric acid, and collecting by filtration the precipitate which forms. The carbamate normally needs no further purification, but if desired it can be crystallized from common solvents, such as benzene, acetone, ethyl acetate, and the like.

Workup

  1. customThe product of the reaction

Sources & evidence

ORD record
ord-d0148d236dd6450187585fca893e2f62
Source dataset
uspto-grants-1986_07
Patent number
US04600430

Reaction notes

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