Ammonia → 4-Cyclopropyl-6-methoxy-1,3,5-triazin-2-amine

HRID 745732Notes

Reaction equation

HRID 745732 reaction equation
[NH3:1].[CH:2]1([C:5]2[N:10]=[C:9]([O:11][CH3:12])[N:8]=[C:7](C(Cl)(Cl)Cl)[N:6]=2)[CH2:4][CH2:3]1>O1CCCC1>[NH2:1][C:7]1[N:6]=[C:5]([CH:2]2[CH2:4][CH2:3]2)[N:10]=[C:9]([O:11][CH3:12])[N:8]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 201996182-Cyclopropyl-4-methoxy-6-(trichloromethyl)-1,3,5-triazine

Product 1

HCID 27265914-Cyclopropyl-6-methoxy-1,3,5-triazin-2-amine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

5 ml of concentrated aqueous ammonia are added to a solution of 1 g of 2-cyclopropyl-4-methoxy-6-trichloromethyl-1,3,5-triazine in 3 ml of tetrahydrofuran; the whole is placed into a bomb tube and heated at 80° C. for 30 minutes. The mixture is cooled and then filtered; the filter residue is dissolved in 30 ml of methylene chloride, and the solution is dried over magnesium sulfate, and concentrated by evaporation. The residue crystallises to leave 0.4 g of white crystals, m.p. 157°-158° C.

Workup

  1. customthe whole is placed into a bomb tube
  2. temperatureThe mixture is cooled
  3. filtrationfiltered
  4. dissolutionthe filter residue is dissolved in 30 ml of methylene chloride
  5. dry with materialthe solution is dried over magnesium sulfate
  6. concentrationconcentrated by evaporation
  7. customThe residue crystallises

Sources & evidence

ORD record
ord-94f811812539495c9a88c420b11fd8f6
Source dataset
uspto-grants-1986_07
Patent number
US04600428

Reaction notes

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