HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2H-Indol-2-one, 5-fluoro-1,3-dihydro-3-Methyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 5-fluoro-1,3-dihydro-2H-indol-2-one | HCID 3731012 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | 2H-Indol-2-one, 5-fluoro-1,3-dihydro-3-Methyl- | HCID 17792875 | — |
Reaction Steps
3.0 g (20 mmol) 5-fluoro-1,3-dihydro-indol-2-one, 50 mL methanol and 2.0 g Raney nickel were stirred for 1.5 h at 200° C. in an autoclave. After the catalyst had been filtered off the mother liquor was evaporated down and the residue was recrystallised from methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829006B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-66f7b41e2bb846d29f2c245d616c90b3 |
| Source note | uspto-grants-2014_09 |