Hydrochloric Acid → HCID 23312093, compound

Participants

Reaction Steps

22.8 g (0.059 mole) of ethyl 5-chloro-6-(3-fluorophenylsulfonyl)-1,3-benzodioxole-2-carboxylate are covered with 90 ml of 2-n sodium hydroxide solution and the batch is heated for half an hour in a boiling water bath, cooled, acidified with hydrochloric acid and then extracted with ethyl acetate. The extract is concentrated by evaporation, affording 5-chloro-6-(3-fluorophenylsulfonyl)-1,3-benzodioxole-2-carboxylic acid. Melting point 161°-163° C. (crystallisation from ether/toluene).

Provenance & Evidence