Hydrochloric Acid → HCID 23312093, compound

HRID 745809Notes

Reaction equation

HRID 745809 reaction equation
[Cl:1][C:2]1[C:15]([S:16]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=2)(=[O:18])=[O:17])=[CH:14][C:5]2[O:6][CH:7]([C:9]([O:11]CC)=[O:10])[O:8][C:4]=2[CH:3]=1.[OH-].[Na+].Cl>>[Cl:1][C:2]1[C:15]([S:16]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=2)(=[O:18])=[O:17])=[CH:14][C:5]2[O:6][CH:7]([C:9]([OH:11])=[O:10])[O:8][C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23312039HCID 23312039, compound

Product 1

HCID 23312093HCID 23312093, compound

Procedure

22.8 g (0.059 mole) of ethyl 5-chloro-6-(3-fluorophenylsulfonyl)-1,3-benzodioxole-2-carboxylate are covered with 90 ml of 2-n sodium hydroxide solution and the batch is heated for half an hour in a boiling water bath, cooled, acidified with hydrochloric acid and then extracted with ethyl acetate. The extract is concentrated by evaporation, affording 5-chloro-6-(3-fluorophenylsulfonyl)-1,3-benzodioxole-2-carboxylic acid. Melting point 161°-163° C. (crystallisation from ether/toluene).

Workup

  1. temperaturethe batch is heated for half an hour in a boiling water bath
  2. temperaturecooled
  3. extractionextracted with ethyl acetate
  4. concentrationThe extract is concentrated by evaporation

Sources & evidence

ORD record
ord-508da0edda3b47aaa07130ec00f69db7
Source dataset
uspto-grants-1986_07
Patent number
US04600709

Reaction notes

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