Acetic Acid → 2,3-dihydro-3-oxo-1H-isoindole-5-sulfonamide hydrochloride

HRID 745832ノート

反応式

HRID 745832 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=[O:26])[N:7](C3CCN(CC4C=CC(Cl)=CC=4)CC3)[C:8]2=O)=[CH:4][C:3]=1[S:27]([NH2:30])(=[O:29])=[O:28].O=C1C2C(=CC=CC=2)C(=O)N1.C(O)(=O)C.C(OCC)(=O)C>CO.[Zn]>[ClH:1].[O:26]=[C:6]1[C:5]2[C:9](=[CH:10][CH:2]=[C:3]([S:27]([NH2:30])(=[O:28])=[O:29])[CH:4]=2)[CH2:8][NH:7]1

参加物

7

反応物 4

HCID 176Acetic AcidHCID 6809PhthalimideHCID 8857Ethyl AcetateHCID 133706026-chloro-2-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-2,3-dihydro-1,3-dioxo-1H-isoindole-5-sulfonamide

生成物 1

HCID 233124542,3-dihydro-3-oxo-1H-isoindole-5-sulfonamide hydrochloride

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 887Methanol溶媒

実験手順

Reduction of the above product (a) 1,3-dioxoisoindole (5.0 g., 0.0107 mole) with zinc and acetic acid according to the method of Example 1(c) and conversion of the free base (partially purified by trituration with ethyl acetate) to the hydrochloride salt in methanol afforded 6-chloro-2-[1-[(4-chloro-phenyl)-phenyl)methyl]-4-piperidinyl]-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonamide hydrochloride as the sesquihydrate, m.p. 256°-260° (dec.).

出典と根拠

ORDレコード
ord-a5f54760501c4ddda1262e3213b381ba
出典データセット
uspto-grants-1986_07
特許番号
US04600758

反応ノート

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