HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2,3-dihydro-3-oxo-1H-isoindole-5-sulfonamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Phthalimide | HCID 6809 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 6-chloro-2-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-2,3-dihydro-1,3-dioxo-1H-isoindole-5-sulfonamide | HCID 13370602 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2,3-dihydro-3-oxo-1H-isoindole-5-sulfonamide hydrochloride | HCID 23312454 | — |
Reaction Steps
Reduction of the above product (a) 1,3-dioxoisoindole (5.0 g., 0.0107 mole) with zinc and acetic acid according to the method of Example 1(c) and conversion of the free base (partially purified by trituration with ethyl acetate) to the hydrochloride salt in methanol afforded 6-chloro-2-[1-[(4-chloro-phenyl)-phenyl)methyl]-4-piperidinyl]-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonamide hydrochloride as the sesquihydrate, m.p. 256°-260° (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04600758 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-a5f54760501c4ddda1262e3213b381ba |
| Source note | uspto-grants-1986_07 |