Hydrochloric Acid → HCID 178483233, compound

HRID 745866Notes

Reaction equation

HRID 745866 reaction equation
[NH2:1][C:2]1[C:6]([NH:7][CH2:8][CH2:9][S:10][CH2:11][C:12]2[O:13][C:14]([CH2:17][N:18]([CH3:20])[CH3:19])=[CH:15][CH:16]=2)=[N:5]S(=O)[N:3]=1.[ClH:22]>CO>[OH2:13].[ClH:22].[ClH:22].[ClH:22].[CH3:20][N:18]([CH2:17][C:14]1[O:13][C:12]([CH2:11][S:10][CH2:9][CH2:8][NH:7][C:6](=[NH:5])[C:2](=[NH:1])[NH2:3])=[CH:16][CH:15]=1)[CH3:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 5384819CHEMBL8982

Product 1

HCID 178483233HCID 178483233, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 3-amino-4-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide (6.59 g; 20.0 mmoles) [prepared according to published United Kingdom Patent Application No. 2,067,987] in 200 mL of methanol was warmed slightly to achieve complete solution, then treated with 13.3 mL of concentrated HCl. After stirring at ambient temperature for 2.5 hours, the solution was concentrated and the residue was triturated with 70 mL of absolute ethanol. The crystals were collected by filtration and dried under vacuum to give 4.3 g (52%) of the title compound, m.p. 166°-169° C. (dec.).

Workup

  1. temperaturewas warmed slightly
  2. concentrationthe solution was concentrated
  3. customthe residue was triturated with 70 mL of absolute ethanol
  4. filtrationThe crystals were collected by filtration
  5. customdried under vacuum

Sources & evidence

ORD record
ord-dc2f759f41b54632b689d51d1a0c3892
Source dataset
uspto-grants-1986_07
Patent number
US04600779

Reaction notes

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