Pyrrolidine → HCID 23311168, compound

HRID 745934Notes

Reaction equation

[CH:1]1([C:7]2([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:11]3[CH:12]=[N:13][C:14]([CH2:24]Cl)=[C:15]([O:16]CC4C=CC=CC=4)[C:10]=3[CH2:9][O:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1>>[CH:1]1([C:7]2([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:11]3[CH:12]=[N:13][C:14]([CH2:24][N:32]4[CH2:36][CH2:35][CH2:34][CH2:33]4)=[C:15]([OH:16])[C:10]=3[CH2:9][O:8]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 23311167HCID 23311167, compound

Product 1

HCID 23311168HCID 23311168, compoundYield 67%

Procedure

The method of example 3 was repeated, but starting with 1,3-dihydro-3-cyclohexyl-3-phenyl-6-chloromethyl-7-benzoxy-furo-(3,4-c)-pyridine and with pyrrolidine instead of dimethylamine. Yield 67% of a yellow crystalline product melting at 204° C. (Tottoli), elemental analysis of which showed a good correspondence with the formula C24H30N2O4.

Sources & evidence

ORD record: ord-8c01bc632ed94529a7b76d907126b647
Source dataset: uspto-grants-1986_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04602020

Reaction notes

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