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Triethylamine → Ethyl 3-oxo-2-[(3-phenylacryloyl)amino]butanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Phenylprop-2-enoyl chloride | HCID 66023 | — |
| 反応物 | Ethyl 2-amino-3-oxobutanoate hydrochloride | HCID 13282897 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Ethyl 3-oxo-2-[(3-phenylacryloyl)amino]butanoate | HCID 53679532 | — |
反応手順
Triethylamine (8.3 ml) was added dropwise to a solution of ethyl 2-aminoacetoacetate hydrochloride (5.43 g) and cinnamoyl chloride (5.0 g) in chloroform (90 ml) with ice-cooling and stirring. After 20 minutes, the mixture was washed with water and dried over anhydrous magnesium sulfate. The solvent was then distilled off and the residue was treated with isopropyl ether to give ethyl 2-cinnamoylaminoacetoacetate as crystals; yield 6.1 g (73.9%). Recrystallization from ethanol gave colorless needles melting at 113°-114° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04602027 |
| 出典データセット | uspto-grants-1986_07 |
| ORD ID | ord-8efedca953ae43c2bed0b67ab6331cf5 |
| 出典メモ | uspto-grants-1986_07 |