反应详情

32 g (0.20 mol) 2-chloro-5-nitropyridine in 120 mL toluene were combined with 200 mL (0.20 mmol) of a 1M sodium benzylate solution in benzylalcohol and stirred overnight at RT. The organic phase was washed with water and saturated sodium chloride solution, dried on sodium sulphate and the toluene was eliminated by distillation. The residue was cooled with ice, the precipitate formed was suction filtered and washed several times with tert.-butylmethylether.

1. washThe organic phase was washed with water and saturated sodium chloride solution
2. customdried on sodium sulphate
3. distillationthe toluene was eliminated by distillation
4. temperatureThe residue was cooled with ice
5. customthe precipitate formed
6. filtrationfiltered
7. washwashed several times with tert.-butylmethylether