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HRID746115

反应详情

EQUATION

反应方程式

HRID 746115 的结构方程式

REACTANTS

反应物

3
结构：CCO
HCID702

Ethanol

C2H6O

结构：CCOC(=O)C1C(=O)N(C)C(=O)N(C)C1=O
HCID593714

未命名化合物

结构：Nc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1
HCID2783085

4-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}aniline

C12H9F3N2O

PRODUCTS

生成物

1
结构：CN1C(=O)C(C(=O)Nc2ccc(Oc3ccc(C(F)(F)F)cn3)cc2)C(=O)N(C)C1=O
HCID20240708

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

1.60 g (0.007 mol) of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid and 1.78 g (0.007 mol) of 4-(5-trifluoromethylpyrid-2-yloxy)aniline are suspended in 20 ml of toluene. The suspension is heated to reflux for 16 hours, during which time ethanol escapes. After cooling, the precipitate is isolated by filtration, washed with toluene and dried, affording 1,3-dimethyl-5-[4-(5-trifluoromethylpyrid-2-yloxy)phenylcarbamoyl]barbituric acid of the formula ##STR24## with a melting point of 180°-181° C.

WORKUP

后处理

  1. temperatureThe suspension is heated
  2. temperatureAfter cooling
  3. customthe precipitate is isolated by filtration
  4. washwashed with toluene
  5. customdried