Ethanol → HCID 20240708, compound

HRID 746115Notes

Reaction equation

HRID 746115 reaction equation
[CH3:1][N:2]1[C:9](=[O:10])[CH:8]([C:11]([O:13]CC)=O)[C:6](=[O:7])[N:5]([CH3:16])[C:3]1=[O:4].[F:17][C:18]([F:34])([F:33])[C:19]1[CH:20]=[CH:21][C:22]([O:25][C:26]2[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=2)=[N:23][CH:24]=1.C(O)C>C1(C)C=CC=CC=1>[CH3:16][N:5]1[C:6](=[O:7])[CH:8]([C:11](=[O:13])[NH:30][C:29]2[CH:31]=[CH:32][C:26]([O:25][C:22]3[CH:21]=[CH:20][C:19]([C:18]([F:34])([F:17])[F:33])=[CH:24][N:23]=3)=[CH:27][CH:28]=2)[C:9](=[O:10])[N:2]([CH3:1])[C:3]1=[O:4]

Participants

5

Reactant 3

HCID 702EthanolHCID 5937141,3-Dimethyl-5-ethoxycarbonylbarbituric acidHCID 27830854-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}aniline

Product 1

HCID 20240708HCID 20240708, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1.60 g (0.007 mol) of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid and 1.78 g (0.007 mol) of 4-(5-trifluoromethylpyrid-2-yloxy)aniline are suspended in 20 ml of toluene. The suspension is heated to reflux for 16 hours, during which time ethanol escapes. After cooling, the precipitate is isolated by filtration, washed with toluene and dried, affording 1,3-dimethyl-5-[4-(5-trifluoromethylpyrid-2-yloxy)phenylcarbamoyl]barbituric acid of the formula ##STR24## with a melting point of 180°-181° C.

Workup

  1. temperatureThe suspension is heated
  2. temperatureAfter cooling
  3. customthe precipitate is isolated by filtration
  4. washwashed with toluene
  5. customdried

Sources & evidence

ORD record
ord-ad9e6b3518fe46199102c704e4503b77
Source dataset
uspto-grants-1986_07
Patent number
US04602912

Reaction notes

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