HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 20240708, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 1,3-Dimethyl-5-ethoxycarbonylbarbituric acid | HCID 593714 | — |
| Reactant | 4-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}aniline | HCID 2783085 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 20240708 | HCID 20240708 | — |
Reaction Steps
1.60 g (0.007 mol) of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid and 1.78 g (0.007 mol) of 4-(5-trifluoromethylpyrid-2-yloxy)aniline are suspended in 20 ml of toluene. The suspension is heated to reflux for 16 hours, during which time ethanol escapes. After cooling, the precipitate is isolated by filtration, washed with toluene and dried, affording 1,3-dimethyl-5-[4-(5-trifluoromethylpyrid-2-yloxy)phenylcarbamoyl]barbituric acid of the formula ##STR24## with a melting point of 180°-181° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04602912 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-ad9e6b3518fe46199102c704e4503b77 |
| Source note | uspto-grants-1986_07 |