Sodium Hydroxide → HCID 58386564, compound

HRID 74615Notes

Reaction equation

HRID 74615 reaction equation
[O:1]=[C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[N:3]1[CH:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][N:20]=[C:19]([C:23]([O:25]C)=[O:24])[N:18]=2)[CH2:13][CH2:12]1.[OH-].[Na+]>O1CCCC1>[O:1]=[C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[N:3]1[CH:11]1[CH2:12][CH2:13][N:14]([C:17]2[CH:22]=[CH:21][N:20]=[C:19]([C:23]([OH:25])=[O:24])[N:18]=2)[CH2:15][CH2:16]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58386569HCID 58386569, compound

Product 1

HCID 58386564HCID 58386564, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.50 g (1.4 mmol) methyl 4-[4-(2-oxo-2,3-dihydro-imidazo[4,5-b]pyridin-1-yl)-piperidin-1-yl]-pyrimidine-2-carboxylate, 1.1 mL d-water and 1.1 mL 4 M sodium hydroxide solution in 9.0 mL tetrahydrofuran was stirred overnight at RT. The organic solvent was removed and the residue was diluted with 250 mL water. After the addition of 25 mL 4M hydrochloric acid solution the mixture was stirred for 1 h. The precipitated solid was suction filtered, washed with water and dried.

Workup

  1. customThe organic solvent was removed
  2. additionthe residue was diluted with 250 mL water
  3. additionAfter the addition of 25 mL 4M hydrochloric acid solution the mixture
  4. filtrationfiltered
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-4d613ac0cc364fb9b14e25f1e0a01ec0
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Reaction notes

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