反应详情

0.50 g (1.4 mmol) methyl 4-[4-(2-oxo-2,3-dihydro-imidazo[4,5-b]pyridin-1-yl)-piperidin-1-yl]-pyrimidine-2-carboxylate, 1.1 mL d-water and 1.1 mL 4 M sodium hydroxide solution in 9.0 mL tetrahydrofuran was stirred overnight at RT. The organic solvent was removed and the residue was diluted with 250 mL water. After the addition of 25 mL 4M hydrochloric acid solution the mixture was stirred for 1 h. The precipitated solid was suction filtered, washed with water and dried.

1. customThe organic solvent was removed
2. additionthe residue was diluted with 250 mL water
3. additionAfter the addition of 25 mL 4M hydrochloric acid solution the mixture
4. filtrationfiltered
5. washwashed with water
6. customdried