HCID 178470300, compound → HCID 178431784, compound

HRID 74617Notes

Reaction equation

HRID 74617 reaction equation
[OH:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([O:10]CC)=[O:9])[C:3]=1[CH3:13]>Cl>[OH:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([OH:10])=[O:9])[C:3]=1[CH3:13]

Participants

3

Reactant 1

HCID 178470300HCID 178470300, compound

Product 1

HCID 178431784HCID 178431784, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

5.0 g (27 mmol) ethyl 6-hydroxy-5-methyl-pyrimidine-4-carboxylate were dissolved in 20 mL concentrated hydrochloric acid and stirred overnight at RT. Then the reaction mixture was heated to 75° C. and stirred for 6 h. The reaction mixture was cooled to 5° C., suction filtered, washed with 2 mL concentrated hydrochloric acid and dried.

Workup

  1. temperatureThen the reaction mixture was heated to 75° C.
  2. stirringstirred for 6 h
  3. temperatureThe reaction mixture was cooled to 5° C.
  4. filtrationsuction filtered
  5. washwashed with 2 mL concentrated hydrochloric acid
  6. customdried

Sources & evidence

ORD record
ord-c790ad55c4c843deba09b7a0577367b2
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Reaction notes

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