反应详情

5.0 g (27 mmol) ethyl 6-hydroxy-5-methyl-pyrimidine-4-carboxylate were dissolved in 20 mL concentrated hydrochloric acid and stirred overnight at RT. Then the reaction mixture was heated to 75° C. and stirred for 6 h. The reaction mixture was cooled to 5° C., suction filtered, washed with 2 mL concentrated hydrochloric acid and dried.

1. temperatureThen the reaction mixture was heated to 75° C.
2. stirringstirred for 6 h
3. temperatureThe reaction mixture was cooled to 5° C.
4. filtrationsuction filtered
5. washwashed with 2 mL concentrated hydrochloric acid
6. customdried