HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzylpiperazine → 2-[(4-Benzylpiperazin-1-yl)methyl]-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | 2-Chloromethylbenzimidazole | HCID 78571 | — |
| Product | 2-[(4-Benzylpiperazin-1-yl)methyl]-1H-benzimidazole | HCID 13656996 | 83.4% |
Reaction Steps
In the same manner as described in Reference Example 4, N-benzylpiperazine (20 g) and 2-chloromethylbenzimidazole (9.0 g) are reacted, and the crude crystal thus obtained is recrystallized from ethyl acetate to give 2-(4-benzyl-1-piperazinyl)methylbenzimidazole (13.8 g) as pale yellow needles, m.p. 195°-201° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04603130 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-d1ebb21bd3514963b1c12edc47e99675 |
| Source note | uspto-grants-1986_07 |