Sodium Iodide → HCID 58754200, compound

HRID 746368Notes

Reaction equation

HRID 746368 reaction equation
Br[CH2:2][C:3]([O:5][CH2:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][C:8]=1[N+:17]([O-:19])=[O:18])=[O:4].[Na+].[I-:21]>CC(C)=O>[I:21][CH2:2][C:3]([O:5][CH2:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][C:8]=1[N+:17]([O-:19])=[O:18])=[O:4]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 860712194.5-Dimethoxy-2-nitrobenzyl 2-bromoacetate

Product 1

HCID 58754200HCID 58754200, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A 4.5-dimethoxy-2-nitrobenzyl 2-bromoacetate (100 mg, 0.3 mmol) was dissolved in acetone (2 ml) and NaI (50 mg, 0.33 mmol) was added. After stirring for two hours at room temperature, mixture was filtered, evaporated and purified by chromatography (Si-gel, CH2Cl2) to yield 4.5-dimethoxy-2-nitrobenzyl 2-iodoacetate (compound E (see FIG. 12c): P6—C1[X═I]) (97 mg, 85%).

Workup

  1. filtrationmixture was filtered
  2. customevaporated
  3. custompurified by chromatography (Si-gel, CH2Cl2)

Sources & evidence

ORD record
ord-f4759bf60ec84a7fb2bbd29a79d5eb81
Source dataset
uspto-grants-2008_07
Patent number
US07393828B2

Reaction notes

Loading…