反应详情

Under a hydrogen atmosphere 30 mg (0.06 mmol) 1-{1-[6-(5-nitro-2,3-dihydro-indole-1-carbonyl)-pyrimidin-4-yl]-piperidin-4-yl}-1,3-dihydro-imidazo[4,5-b]pyridin-2-one and 10 mg palladium on charcoal (10%) were hydrogenated in a 1:1 mixture methanol:THF (5 mL each) at RT and 3 bar hydrogen pressure. Then the catalyst was removed by suction filtering and the filtrate was evaporated down i. vac. The residue was dissolved in 1 mL DMF, filtered through a syringe filter and purified by preparative HPLC. The product fractions were combined and lyophilised.

1. customat RT
2. customThen the catalyst was removed by suction
3. filtrationfiltering
4. customthe filtrate was evaporated down i
5. dissolutionThe residue was dissolved in 1 mL DMF
6. filtrationfiltered through a syringe
7. filtrationfilter
8. custompurified by preparative HPLC