Dimethylamine → HCID 58591573, compound

HRID 746605Notes

Reaction equation

HRID 746605 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:9]=[C:8]([CH2:10][CH2:11]OS(C)(=O)=O)[S:7][C:6]=2[CH:17]=1.[CH3:18][NH:19][CH3:20]>CO>[CH3:18][N:19]([CH3:20])[CH2:11][CH2:10][C:8]1[S:7][C:6]2[CH:17]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]=2[CH:9]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 86602659HCID 86602659, compound

Product 1

HCID 58591573HCID 58591573, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
90 °C

Procedure

In a closed pressure vessel methanesulfonic acid 2-(6-methyl-benzo[b]thiophen-2-yl)-ethyl ester from the previous step was taken up in MeOH (30 mL) and a 40% solution of dimethylamine in MeOH (30 mL) was added. The mixture was stirred for 2 hours at 90° C., cooled down to room temperature and concentrated in vacuo to afford 3.55 g of dimethyl-[2-(6-methyl-benzo[b]thiophen-2-yl)-ethyl]-amine (97%).

Workup

  1. temperaturecooled down to room temperature
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-9553a9383b19497bab8b5fd1edb03f3a
Source dataset
uspto-grants-2008_07
Patent number
US07393865B2

Reaction notes

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