反应详情

Potassium carbonate (46 mg, 0.33 mmol) was added to an acetonitrile (5 ml) solution of this amide (96 mg, 0.3 mmol) and 2-mercaptobenzoxazole (45 mg, 0.3 mmol), and the mixture was stirred at room temperature for 90 minutes. The reaction mixture was diluted with water, and then extracted with ethyl acetate. The organic layer was washed with water and then with a saturated aqueous solution of sodium chloride, and dried over sodium sulfate. Subsequently, the solvent was distilled off, and the resulting crude product was purified through silica gel chromatography (silica gel 10 g, eluent—hexane:acetone=5:2) to obtain 88 mg (yield 75%) of the desired compound as a colorless crystal.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materialwith a saturated aqueous solution of sodium chloride, and dried over sodium sulfate
4. distillationSubsequently, the solvent was distilled off
5. customthe resulting crude product was purified through silica gel chromatography (silica gel 10 g, eluent—hexane:acetone=5:2)