HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 746661Generated: October 26, 2026
2,3-Dihydroxybutanedioic Acid → (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate
https://huagongshe.com/reaction/746661
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,3-Dihydroxybutanedioic Acid | HCID 875 | — |
| Reactant | Tolterodine | HCID 443879 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate | HCID 9847786 | 71.9% |
Reaction Steps
Tolterodine free base (2.0 gm) is dissolved in methyl tert-butyl ether (25 ml), tartaric acid (1.2 gm) is added and the reaction mass is heated to 40° C. Then the contents are cooled to 25° C., maintained for 2 hours at 25° C. to 30° C. and filtered to give 2.1 gm of tolterodine tartrate form III.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07393874B2 |
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| Source dataset | uspto-grants-2008_07 |
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| ORD ID | ord-f76e4e4203d24c6e953c60140ebe904d |
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| Source note | uspto-grants-2008_07 |
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