HCID 178418806, compound → HCID 178503600, compound

HRID 746679Notes

Reaction equation

HRID 746679 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[NH2:19][C:20]1[C:24]([C:25]#[N:26])=[C:23]([S:27][CH3:28])[NH:22][N:21]=1>O1CCCC1>[CH3:28][S:27][C:23]1[NH:22][N:21]=[C:20]([NH:19][CH:8]=[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])[C:24]=1[C:25]#[N:26]

Participants

5

Reactant 3

HCID 178418806HCID 178418806, compoundHCID 178503599HCID 178503599, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178503600HCID 178503600, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 3-amino-5-methylsulfanyl-1H-pyrazole-4-carbonitrile for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.2003 gms. of 3-amino-5-methylsulfanyl-1H-pyrazole-4-carbonitrile by refluxing in tetrahydrofuran (2.5 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-1b0cc799c4244c56ba3e49d4d6c884aa
Source dataset
uspto-grants-2008_07
Patent number
US07393870B2

Reaction notes

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