1H-Pyrazol-3-amine, 5-methyl- → HCID 178428475, compound

HRID 746687Notes

Reaction equation

HRID 746687 reaction equation
O/[CH:2]=[C:3]1\[C:4](=[O:13])[NH:5][C:6]2[C:11]\1=[CH:10][C:9]([F:12])=[CH:8][CH:7]=2.O/C=C1\C(=O)NC2C\1=CC=CC=2.[CH3:26][C:27]1[NH:31][N:30]=[C:29]([NH2:32])[CH:28]=1.NC1C=CNN=1>O1CCCC1>[F:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[NH:5][C:4](=[O:13])[C:3]2=[CH:2][NH:32][C:29]1[CH:28]=[C:27]([CH3:26])[NH:31][N:30]=1

Participants

6

Reactant 4

HCID 931461H-Pyrazol-3-amine, 5-methyl-2×HCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compoundHCID 178517185(3Z)-5-fluoro-3-(hydroxymethylidene)-1H-indol-2-one2×

Product 1

HCID 178428475HCID 178428475, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-5-fluoro-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and 5-methyl-1H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-5-fluoro-1,3-dihydro-indol-2-one (0.050 gms.) is reacted with 0.055 gms. of 5-methyl-1H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (1.5 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-46066b6415ea446195a236b70d8dc822
Source dataset
uspto-grants-2008_07
Patent number
US07393870B2

Reaction notes

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