HCID 178418806, compound → HCID 178424923, compound

HRID 746704Notes

Reaction equation

HRID 746704 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[CH3:19][C:20]1[CH:32]=[C:31]([CH3:33])[CH:30]=[C:29]([CH3:34])[C:21]=1[CH2:22]C1C=C(N)NN=1>O1CCCC1>[CH3:22][C:21]1[C:29]([CH3:34])=[CH:30][C:31]([CH3:33])=[CH:32][C:20]=1[CH2:19][C:5]1[CH:6]=[C:2]([NH:1][CH:8]=[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])[NH:3][N:4]=1

Participants

5

Reactant 3

HCID 178418806HCID 178418806, compoundHCID 178424852HCID 178424852, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178424923HCID 178424923, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 5-(2,4,6-trimethyl-benzyl)-2H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.2758 gms. 5-(2,4,6-trimethyl-benzyl)-2H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (2.0 mL) overnight.

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-e1e028ff28cf4f2ea2b410362f427eb3
Source dataset
uspto-grants-2008_07
Patent number
US07393870B2

Reaction notes

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