HCID 178418806, compound → HCID 178466091, compound

HRID 746710Notes

Reaction equation

HRID 746710 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[CH2:19]([O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:29]=[C:30]([NH2:33])[NH:31][N:32]=2)=[CH:24][CH:23]=1)[CH3:20]>O1CCCC1>[CH2:19]([O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:29]=[C:30]([NH:33][CH:8]=[C:9]3[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[NH:11][C:10]3=[O:18])[NH:31][N:32]=2)=[CH:24][CH:23]=1)[CH3:20]

Participants

5

Reactant 3

HCID 178418806HCID 178418806, compoundHCID 178466095HCID 178466095, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178466091HCID 178466091, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 5-(4-ethoxy-phenyl)-2H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.2635 gms. 5-(4-ethoxy-phenyl)-2H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (2.0 mL) overnight.

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-483d0a95975d4e038f38b8d089a6e321
Source dataset
uspto-grants-2008_07
Patent number
US07393870B2

Reaction notes

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