3-Amino-5-methylisoxazole → HCID 178428474, compound

HRID 746720Notes

Reaction equation

HRID 746720 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[CH3:19][C:20]1[O:24][N:23]=[C:22]([NH2:25])[CH:21]=1>O1CCCC1>[CH3:19][C:20]1[O:24][N:23]=[C:22]([NH:25][CH:8]=[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])[CH:21]=1

Participants

5

Reactant 3

HCID 661723-Amino-5-methylisoxazoleHCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178428474HCID 178428474, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 5-methyl-isoxazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.1228 gms. 5-methyl-isoxazol-3-ylamine by refluxing in tetrahydrofuran (2.7 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-204f0afda8e5411884b5085f9ef3ba81
Source dataset
uspto-grants-2008_07
Patent number
US07393870B2

Reaction notes

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