HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Pyrazol-3-amine, 5-methyl- → HCID 178428476, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Pyrazol-3-amine, 5-methyl- | HCID 93146 | — |
| Reactant | HCID 178418806 | HCID 178418806 | — |
| Reactant | HCID 178517101 | HCID 178517101 | — |
| Reactant | (3Z)-6-fluoro-3-(hydroxymethylidene)-1H-indol-2-one | HCID 178517312 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178428476 | HCID 178428476 | — |
Reaction Steps
The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-6-fluoro-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and 5-methyl-1H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-6-fluoro-1,3-dihydro-indol-2-one (0.033 gms.) is reacted with 0.040 gms. 5-methyl-1H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (0.88 mL) to afford the named compound in the amount of 0.0163 gms.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07393870B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-fe077c41ae5643d48247e0990a4451f6 |
| Source note | uspto-grants-2008_07 |