1H-Pyrazol-3-amine, 5-methyl- → HCID 178428476, compound

HRID 746725Notes

Reaction equation

HRID 746725 reaction equation
O/[CH:2]=[C:3]1\[C:4](=[O:13])[NH:5][C:6]2[C:11]\1=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=2.O/C=C1\C(=O)NC2C\1=CC=CC=2.[CH3:26][C:27]1[NH:31][N:30]=[C:29]([NH2:32])[CH:28]=1.NC1C=CNN=1>O1CCCC1>[F:12][C:8]1[CH:7]=[C:6]2[C:11]([C:3](=[CH:2][NH:32][C:29]3[CH:28]=[C:27]([CH3:26])[NH:31][N:30]=3)[C:4](=[O:13])[NH:5]2)=[CH:10][CH:9]=1

Participants

6

Reactant 4

HCID 931461H-Pyrazol-3-amine, 5-methyl-2×HCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compoundHCID 178517312(3Z)-6-fluoro-3-(hydroxymethylidene)-1H-indol-2-one2×

Product 1

HCID 178428476HCID 178428476, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-6-fluoro-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and 5-methyl-1H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-6-fluoro-1,3-dihydro-indol-2-one (0.033 gms.) is reacted with 0.040 gms. 5-methyl-1H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (0.88 mL) to afford the named compound in the amount of 0.0163 gms.

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1
  3. customto afford the named compound in the amount of 0.0163 gms

Sources & evidence

ORD record
ord-fe077c41ae5643d48247e0990a4451f6
Source dataset
uspto-grants-2008_07
Patent number
US07393870B2

Reaction notes

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