Pyridine → N-(2-benzoylphenyl)-4-nitroBenzenesulfonamide

HRID 746737Notes

Reaction equation

HRID 746737 reaction equation
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[N+:16]([C:19]1[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1)([O-:18])=[O:17].N1C=CC=CC=1>C(Cl)Cl>[C:4]([C:3]1[CH:12]=[CH:13][CH:14]=[CH:15][C:2]=1[NH:1][S:25]([C:22]1[CH:21]=[CH:20][C:19]([N+:16]([O-:18])=[O:17])=[CH:24][CH:23]=1)(=[O:26])=[O:27])(=[O:5])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 74044-Nitrobenzenesulfonyl chlorideHCID 760802-Aminobenzophenone

Product 1

HCID 10474997N-(2-benzoylphenyl)-4-nitroBenzenesulfonamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Aminobenzophenone (20 mg) was dissolved in 1 mL of methylene chloride and 4-nitrobenzenesulfonyl chloride (34 mg, 1.5 equiv) was added thereto followed by pyridine (16 mL, 2 equiv). After 10 minutes the reaction mixture was oncentrated in vacuo, subjected to flash chromatography (eluting with 0% to 25% EtOAc/hexane) to provide N-(2-benzoylphenyl)-4-nitrobenzenesulfonamide. ESMS, M+H+ found: 383.1.

Workup

  1. washsubjected to flash chromatography (eluting with 0% to 25% EtOAc/hexane)

Sources & evidence

ORD record
ord-751a4213bab7459286c4a7dd5c2c3649
Source dataset
uspto-grants-2008_07
Patent number
US07393873B2

Reaction notes

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