反应详情

Add SnCl2 2 H2O (470 mg, 2.8 mmol) to a solution of 6-nitro-4′-[3-(propane-2-sulfonylamino)-thiophen-2-yl]-biphenyl-2-carboxylic acid methyl ester (250 mg, 0.54 mmol) in EtOH (5 mL). Heat the reaction at 80° C. for 3 hours. Add 100 mL EtOAc and wash it with a saturated solution of NaHCO3, water and saturated aq. sodium chloride (50 mL). Dry over NaSO4, filter and evaporate to dryness to provide 6-amino-4′-[3-(propane-2-sulfonylamino)-thiophen-2-yl]-biphenyl-2-carboxylic acid methyl ester (208 mg). MS (m/e): 429.1(M−1).

1. temperatureHeat
2. customthe reaction at 80° C. for 3 hours
3. washwash it with a saturated solution of NaHCO3, water and saturated aq. sodium chloride (50 mL)
4. dry with materialDry over NaSO4
5. filtrationfilter
6. customevaporate to dryness