反应详情

温度

65 °C

To a solution of 2-(2-methoxy-4-nitrophenyl)pyridine (5.4 g, 23.3 mmol), dimethyl hydrazine (14 mL, 233 mmol), charcoal (0.7 g), in methanol (200 mL) was added iron trichloride (0.075 g, 0.46 mmol), then heated at 65° C. overnight. The reaction mixture was quenched with H2O (50 mL), then extracted with EtOAc (3×50 mL) and the combined organic extracts washed with brine. The organic phase was dried over Na2SO4 and concentrated in vacuo. The crude purified by liquid chromatography on silica (EtOAc/Hexane 3/7) to give 3-methoxy-4-pyridin-2-ylaniline.

1. customThe reaction mixture was quenched with H2O (50 mL)
2. extractionextracted with EtOAc (3×50 mL)
3. washthe combined organic extracts washed with brine
4. dry with materialThe organic phase was dried over Na2SO4
5. concentrationconcentrated in vacuo
6. customThe crude purified by liquid chromatography on silica (EtOAc/Hexane 3/7)