Piperidine → 4-Quinolone-3-carboxylic acid
Reaction equation
N[C:2]1[C:11](F)=[C:10](F)[C:9](OC)=[C:8]2[C:3]=1[C:4](=[O:22])[C:5]([C:19]([OH:21])=[O:20])=[CH:6][N:7]2C1CC1.N1CCCCC1>>[O:22]=[C:4]1[C:3]2[C:8](=[CH:9][CH:10]=[CH:11][CH:2]=2)[NH:7][CH:6]=[C:5]1[C:19]([OH:21])=[O:20]Participants
3
Procedure
5-Amino-1-cyclopropyl-6-fluoro-8-methoxy-7-{(4-amino/substituted amino/disubstituted amino/hydroxy-3-alkyl/3,3-dialkyl/3,5-dialkyl/3,3,5-trialkyl)1-1-piperidinyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and isomers were prepared by a procedure described in Method 1 by using 5-amino-1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and appropriate {4-(amino/substituted amino/disubstituted amino/hydroxy-3-alkyl/3,3-dialkyl/3,5-dialkyl/3,3,5-trialkyl)} piperidine.
Sources & evidence
- ORD record
- ord-b4d8f8090bd14683a9532664e9f27b56
- Source dataset
- uspto-grants-2008_07
- Patent number
- US07393957B2
Reaction notes
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